Published May 15, 2000
by Informa Healthcare .
Written in English
|Contributions||Michael Bradbury (Editor), David Begley (Editor), Jorg Kreuter (Editor)|
|The Physical Object|
|Number of Pages||248|
Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews. Central nervous system (CNS) drugs are a leading pharmaceutical area, since many CNS diseases remain untreated or without optimum drugs. Unfortunately, the blood-brain barrier (BBB) restricts access of drug molecules circulating in the blood stream to penetrate into the brain cells – and that is where this important book steps : $ CNS drug delivery is complicated by the blood–brain barrier and by the functional changes that occur after acute stroke, which can prevent CNS localization. These functional changes cause variability in blood–brain barrier permeability and decrease penetrance of therapeutics. This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB. It contains cutting-edge methods for studying drug delivery and administering drugs into the brain.
Overview. The delivery of drugs to the brain is a challenge in the treatment of CNS disorders. The major obstruction to CNS drug delivery is the blood-brain barrier, which limits the access of drugs to the brain article describes various strategies to facilitate drug delivery to the brain in neurologic disorders. Intranasal administration is a noninvasive delivery route to bypass the blood–brain barrier, while direct brain administration is an invasive mode to target the brain region with therapeutic drug concentrations locally. Nowadays, both technological and mechanistic tools are available to assist in overcoming the blood–brain by: This supports the development of nanotechnologies that can potentially carry out multiple specific functions at once or in a predefined sequence, which is an important property for the clinically successful delivery of drugs and other molecules to the central nervous system (CNS). An ability to cross the blood-brain barrier (BBB) to deliver. Transport routes across the blood-brain barrier (BBB) and strategies for delivery of central nervous system (CNS)-active therapeutics across the BBB include physical/chemical disruption, enhanced transcytosis (e.g., drug modification, transporter-mediated, or receptor-mediated pathway), nanoparticle-based delivery, and cell-based delivery.
Blood-brain barrier structure and function and the challenges for CNS drug delivery. Abbott NJ(1). Author information: (1)BBB Group, Institute of Pharmaceutical Science, King's College London, London, UK. @d by: The blood-brain barrier (BBB) efficiently restricts penetration of therapeutic agents to the brain from the periphery. Therefore, discovery of new modalities allowing for effective delivery of drugs and biomacromolecules to the central nervous system (CNS) is of great need and importance for treatment of neurodegenerative disorders. Blood-Brain Barrier and CNS Drug Delivery Parvin Zakeri-Milani, Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran. The central nervous system is protected by barriers which control the passage of various chemical substances and microscopic objects, thereby regulating brain . Going digital in its 2nd year, the Blood-Brain Barrier (BBB) Summit is the industry’s definitive BBB conference focused on sharing the latest scientific advances, data and key lessons learned for transporting more drugs across the BBB.